Mayersville is a town on the east bank of the Mississippi River, and the county seat for Issaquena County, Mississippi, United States. It is located in the Mississippi Delta region, known for cotton cultivation in the antebellum era. Once the trading center for the county, the town was superseded when railroads were built into the area. As of the 2020 census, Mayersville had a population of 433.

From Wikipedia, licensed CC BY-SA 4.0 · facts via Wikidata (CC0)

Town numbers

ZIP code39113

Area code662

Living in Mayersville

Work & commute in Mayersville

Full picture →

Most working residents leave Mayersville for work: only 12% work in town. The top destinations are Rolling Fork (11%), Jackson (9%) and Pearl (5%). Half commute less than 58 miles.

Rolling Fork

11%

Jackson

Pearl

Vicksburg

12%Work in townlive and work in Mayersville 58 miWhere do people commute?the commute map 67Jobs based herebalanced

Census LEHD 2023 · ACSWork & commute in Mayersville →

Health in Mayersville

Compared with Mississippi

4better than MS·18worse

of 32 measures CDC estimates. The other 10 are too close to call.

Conditions 4▲ 3▼ 5 close Habits 2▼ 2 close Care 6▼ 1 close Mind 3▼ 2 close Everyday needs 4▼ 0 close

BetterToo close to callWorse

What stands out

3.7%Fewer adults who have had cancerMS 7.6% · better 14.9%Fewer adults with depressionMS 19.5% · better 26.6%More uninsured adultsMS 11.5% · worse

Care nearby

East Carroll Parish HospitalLake Providence · 9.3 mi · ER

East Carroll Parish HospitalLake Providence · 9.4 mi · sliding-scale fees

Primary careShortage · county-wide

DentalShortage · county-wide

Mental healthShortage · county-wide

CDC PLACES 2025 · modeled estimates for adults · CDC's estimate for Mayersville · CMS · HRSAHealth in Mayersville →

Natural hazards in Mayersville

High

Expected storm and flood damage is higher than in 74% of U.S. communities.

🌊 Inland flooding🌵 Drought🌪️ Tornadoes

8Does Mayersville flood?paid flood claims since 1983 4Disasters that paid out herefederal disasters sent FEMA money to Mayersville

FEMA National Risk Index December 2025 · OpenFEMANatural hazards in Mayersville →

Climate in Mayersville

Full climate →

Mayersville has mild winters and hot summers, with plenty of rain. A typical July afternoon reaches 92°, a January night drops to 36°, and snow is almost unheard of.

57° / 38°Winter

76° / 54°Spring

91° / 71°Summer

77° / 54°Fall

How much snow does Mayersville get?Almost none.Rain & snow →When is the first frost?Around Nov 20, with the last in spring around Mar 5.Frost dates →Is it warmer than it used to be?+1.0° vs. the 20th century.Then & now →

NOAA U.S. Climate Normals, 1991–2020Climate in Mayersville →