Arthur L. Newton
1883–1950 American athlete
Preston Cloud
1912–1991 American earth scientist, biogeologist, cosmologist, and paleontologist
Joseph Steward
1753–1822 American artist
RB Rachel Bloznalis
born 1995 American soccer player
Doc Curley
1874–1920 American baseball player
Elijah B. Stoddard
1826–1903 American mayor
Leon Dexter Batchelor
1884–1958 American horticulture proffesor
Guy W. Fiske
1924–2021 American businessman
Samuel N. Aldrich
1838–1908 Politician in Massachusetts, US
Samuel Taft
1735–1816 American militiaman
Also called Upton home
Charles Augustine Davis
1847–1903 Politician in Massachusetts, US