San Luis
About San Luis
City in Arizona, United StatesSan Luis is a city in Yuma County, Arizona, United States. The population was 35,257 at the 2020 census. It is part of the Yuma County Metropolitan Statistical Area. San Luis, located in the southwest corner of the state directly adjacent to Mexico's Federal Highway 2 at San Luis Río Colorado, Sonora, was the second fastest-growing city or town in Arizona from 1990 to 2000. According to 2025 Census Bureau estimates, the population of the city is 42,030.
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